To explore the hypothesis that deranged flow of the cerebrospinal fluid (CSF) due to craniocervical obstructions and/or instability may cause deranged intracranial pressure (ICP), neuroinflammation and cardinal symptoms of ME/CFS.
The IRB review will kick off shortly.
The overall aim is to explore the hypothesis that deranged flow of the cerebrospinal fluid (CSF) due to craniocervical obstructions and/or instability may cause deranged intracranial pressure (ICP), neuroinflammation and cardinal symptoms of ME/CFS. If this hypothesis proves true it opens a new research area in ME/CFS and hopes for effective treatment to regulate ICP and relieve symptoms associated with ME/CFS. This study will make use of CNS imaging and analysis of CSF, blood, saliva samples, and will identify proteomic and metabolomic biomarkers of the disease, a highly needed tool in the diagnostic and prognostic process. By the combination of more detailed clinical examination and evaluation and multiOmics biomarker analysis we will be able to provide a more individually adapted care and hopefully cure.
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