What kind of
life will you live

when there is finally a cure?

Together, we can move ME/CFS & Long COVID research further, faster.

Life Altering Diseases

With ME/CFS or Long COVID, your old life fades away. You lose contact with family and friends. You have to explain your illness again and again. Even your doctor doesn’t understand what is happening to you. 

You are not alone. A staggering 85 million individuals face multisystem diseases like ME/CFS and Long COVID.

Complex diseases require collaboration

ME/CFS and Long COVID disrupt many body systems. Traditional research looks at one system at a time. That approach doesn’t work.

That’s where Open Medicine Foundation (OMF) comes in.  As a nonprofit, we’ve raised $45 million to fund multisystem collaborative research.  OMF brings world-renowned scientists together to study, diagnose, treat, and cure complex diseases.

It’s a bold dream.  It’s the path that will get you back to a fulfilling life.   


total Studies funded by OMF

How do you get to an answer faster?


Once we understand how ME/CFS and Long COVID develop, researchers can pinpoint targets for intervention.


ME/CFS and Long COVID are difficult conditions to diagnose. We need specific biomarkers and definitive tests. 


Currently, there are very few treatments and they only target symptoms. OMF will launch treatment trials in 2023.

access to
quality care

OMF provides medical education to help healthcare providers understand the challenges of multisystem disease.

More than 200 researchers in your corner

You shouldn’t have to struggle alone

We get it. We, too, are patients, parents, or partners of someone with multisystem disease. We are passionate about finding a cure.

At OMF, research is a team sport. We take a systems biology approach at our seven global Collaborative Research Centers. We have a world-renowned Scientific Advisory Board overseeing the process. Instead of waiting on publications, we share results in real-time. 

OMF believes multisystem disease should not be a life sentence but a solvable puzzle.

OMF funded centers

The power of collaborative research

Our Collaborators

Neuroendocrine System: Dysfunctions in the hypothalamic-pituitary-adrenal (HPA) axis and hypothalamic-pituitary-gonadal (HPG) axis have been observed, leading to abnormalities in stress response, sex hormone levels, and autonomic nervous system regulation. 


Immune System: The immune system is composed of white blood cells, antibodies, and other components. It defends the body against infections and diseases, helping to maintain overall health


Cardiovascular System:  The cardiovascular system, comprising the heart, blood vessels, and blood, is responsible for transporting oxygen, nutrients, hormones, and waste products throughout the body. Its efficient functioning ensures the delivery of essential substances and the removal of waste products.


Metabolism:  Metabolism involves dysregulation in energy production, particularly in ATP synthesis and mitochondrial function. Abnormalities in carbohydrate, lipid, and amino acid metabolism have also been observed. Understanding these metabolic dysfunctions can lead to symptoms such as fatigue and muscle pain.


Genetics: Genetics may contribute to an individual's susceptibility to multisystem disease, including variations in immune system genes, genes involved in energy metabolism, and genes related to neurotransmitter function. 


Multiomics:  Multiomics combines various omics technologies such as genomics, transcriptomics, and proteomics. By analyzing multiple layers of biological data, multiomics provide a comprehensive understanding of the molecular mechanisms underlying multisystem diseases. 


Diagnostics:  Diagnostic studies help identify specific biomarkers, imaging techniques, and diagnostic criteria that aid in distinguishing different diseases within the multisystem spectrum. 


Treatments:  Treatment studies evaluate the efficacy and safety of potential interventions. By conducting rigorous clinical trials and treatment studies, researchers can refine existing therapies, develop new interventions, and provide evidence-based guidelines for healthcare providers. 


Systems Biology

Systems biology:  Systems biology is an interdisciplinary approach that combines biology, mathematics, and computational analysis. It helps identify key pathways, biomarkers, and potential therapeutic targets, leading to personalized and more effective treatments for multisystem disease patients.


Pathogens:  Infections can trigger or exacerbate symptoms, leading to increased fatigue, pain, and cognitive difficulties. Pathogens can also contribute to immune system dysregulation and inflammation. 

We take a multisystem approach

By funding studies that examine multiple systems, researchers can see how ME/CFS and Long COVID develop. This approach will lead to more effective treatments and improved quality of life.

Click on each system to read a description.

Your life is too important to live in the shadows.

What will happen if research remains focused on one system at a time?

How will your life shrink? How many graduations, birthday parties, or everyday activities will you miss? What will happen with your career?

Something has to change. 

Why donate to OMF?


Global Collaborations

OMF partners with leading research institutions worldwide.


World-Renowned Scientists

OMF brings together brilliant scientists from around the globe.


Raised to fund research

Collaborative multisystem research will unlock the door to treatments and cures. With your help, we can get to life-changing answers faster.

How It Works

OMF’s research process


You donate

With your support, OMF funds groundbreaking research and medical education. We bring hope to those who need it most.


Researchers collaborate

We bring together top researchers in multiple specialties —  scientists dedicated to diagnosing, treating, and ultimately curing ME/CFS and Long COVID. They share data, collaborate, and build on each other’s work. 


Light bulb moment

Even small breakthroughs can make a big difference when scientists share their ideas.


Communication is key

Unlike traditional research, we don’t wait for publication before we communicate our findings. We regularly post research updates on our website and through email. Make sure you subscribe to our latest news.

Go ahead.

Imagine your life when there is a cure.

Get your copy

ME/CFS and Long COVID fact sheets

What is ME/CFS download header

Perfect For Printing And Sharing With Your Doctor Or Personal Community.

Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation®

What are the advantages of giving from your Donor Advised Fund (DAF)?

  • Your gifts to your donor advised fund entitle you to an immediate income tax deduction at the time of contribution.
  • You avoid capital gains tax on appreciated assets you place in your donor advised fund.
  • Your fund’s investment gains accumulate tax free.
  • Funds are distributed to Open Medicine Foundation in your name and immediately put to use to support our worldwide research efforts.

How do I make a donation through my DAF?

Just click on the DAF widget below. It is simple and convenient to find your fund among the over 900 funds in our system.

Still can’t find your fund? 

  • Request a grant distribution through your Donor Advised Fund sponsor
  • Be sure to use OMF’s EIN #26-4712664
  • You can also designate OMF as a beneficiary for your Donor Advised Fund
  • Questions? Give us a call at 650-242-8669