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Targeted Markers of ME/CFS and Post-COVID

Study Aim

This project aims to investigate specific markers of ME/CFS and Post-COVID identified through previous research.

Investigators

  • Jonas Bergquist, MD, PhD
  • Liudmyla Tsiukalo, PhD

Updates and Potential

  • Subgroup analysis is ongoing.

STUDY HYPOTHESIS AND DESCRIPTION

Prior research has indicated that prolactin, brain-derived neurotrophic factor (BDNF), and neurofilament light chain (NfL) are present at altered levels in people with ME/CFS. Each of these molecules have implications for neurons and brain function.

Prolactin is a hormone that influences neuronal excitability and differentiation. BDNF is a protein that impacts the growth and function of neurons. The NfL is part of a neuron’s structure. Presence of NfL in the cerebrospinal fluid and blood indicate that neurons have been injured.

We hypothesize that the levels of these specific molecules are different in people with ME/CFS and post-COVID when compared to controls. We would expect prolactin and BDNF levels to be low and NfL levels to be high in the plasma, which would correlate to reduced cognitive function

OBJECTIVES

Human brain scan in a neurology clinic

  1. Perform targeted analysis of plasma prolactin levels via an ELISA.
  2. Perform targeted analysis of plasma BDNF levels via an ELISA.
  3. Perform targeted analysis of plasma NfL levels via a SIMOA assay.
  4. Identify clinically relevant subgroups based on prolactin, BDNF, and NfL levels in combination with cognitive function.

Consent management

Consent Preferences

Data Subject Access Request (DSAR) Form 

Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation®

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